UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q96PE1
Entry Name

AGRA2_HUMAN
Protein Name

Adhesion G protein-coupled receptor A2
Primary Gene Name

ADGRA2
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Adhesion G Protein-Coupled Receptor A2(TEM5,ADGRA2)
Cell Type
Substrate Description adhesion-class G protein-coupled receptor, angiogenesis
Substrate Function Category angiogenesis
Substrate Function Subtype
Sheddase MMP9
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers soluble TEM5 (shed by MMP9) mediated endothelial cell adhesion by interaction with integrin αvβ3 and binds to glycosaminoglycans.
Cleavage Information NONE
PMID 16982628



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		34 771
Transmembrane
 		772 792
Transmembrane
 		808 828
Extracellular
 		829 832
Transmembrane
 		833 853
Transmembrane
 		887 907
Extracellular
 		908 924
Transmembrane
 		925 945
Transmembrane
 		1020 1040
Extracellular
 		1041 1047
Transmembrane
 		1048 1068



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information MMP9 16982628   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692