UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q96NY8
Entry Name

NECT4_HUMAN
Protein Name

Nectin-4
Primary Gene Name

NECTIN4
Organism

Homo sapiens (Human)
Molecular Function

Host cell receptor for virus entry
Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Nectin 4
Cell Type breast carcinoma cells
Substrate Description serum marker
Substrate Function Category disease
Substrate Function Subtype Disease: Cancers (breast cancer)
Sheddase ADAM17
Shedding-related Disease cancer (breast cancer)
Short Summary of Papers shed soluble Nectin-4 as serological marker for breast carcinoma
Cleavage Information NONE
PMID 15784625



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 349
Transmembrane
 		350 370



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER RCPA*GELE 31 UNKNOWN Mass spectrometry 33796845   
PAPER DPQE*DSGK 337 UNKNOWN Mass spectrometry 33796845   
PAPER No_information ADAM17 15784625   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16948836
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(ovarian cancer) 23805888