UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q96JA1
Entry Name

LRIG1_HUMAN
Protein Name

Leucine-rich repeats and immunoglobulin-like domains protein 1
Primary Gene Name

LRIG1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Lrig1
Cell Type
Substrate Description negative regulator of growth factor signaling. negative regulator of signaling by receptor tyrosine kinases, enhancement of receptor ubiquitination and accelerated intracellular degradation
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease integral membrane protein
Short Summary of Papers LRIG1 ectodomain can be proteolytically shed and can function as a non-cell-autonomous regulator of growth factor signaling
Cleavage Information NONE
PMID 21087604



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		35 794
Transmembrane
 		795 815



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 21087604   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Plasma/Serum 12917320
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Liver metastasis in colorectal cancer) 23443137