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| UniProt ID |
Q92854 |
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| Entry Name |
SEM4D_HUMAN |
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| Protein Name |
Semaphorin-4D |
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| Primary Gene Name |
SEMA4D |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Semaphorin-4D (sema4D,CD100) | |
| Cell Type | platelet | |
| Substrate Description | platelet activation and adhesion | |
| Substrate Function Category | blood and homoeostasis | |
| Substrate Function Subtype | platelet | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | platelet (thrombus formation) integral membrane protein | |
| Short Summary of Papers | cleavage of sema4D, releases a soluble fragment that may contribute to wound healing through it effects on endothelial cells | |
| Cleavage Information | NONE | |
| PMID | 17244710 |
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Start | End |
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22 | 734 |
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735 | 755 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | PLAF*CGKH | 502 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | 17244710 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |