UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q92823
Entry Name

NRCAM_HUMAN
Protein Name

Neuronal cell adhesion molecule
Primary Gene Name

NRCAM
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Nr-CAM
Cell Type
Substrate Description cell-cell contacts in brain and in the peripheral nervous system. cell-cell contacts between Schwann cells and axons. neurite outgrowth in response to contactin binding
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease cell adhesion molecule
Short Summary of Papers shed etodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation.
Cleavage Information NONE
PMID 16357171



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 1167
Transmembrane
 		1168 1190



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER MISA*LEVP 29 UNKNOWN Mass spectrometry 33796845   
PAPER IDPR*ENIV 61 UNKNOWN Mass spectrometry 33796845   
PAPER VIQC*EAKG 68 UNKNOWN Mass spectrometry 33796845   
PAPER LIIN*IMSE 107 UNKNOWN Mass spectrometry 33796845   
PAPER VYQC*TARN 123 UNKNOWN Mass spectrometry 33796845   
PAPER QSGQ*SLVL 161 UNKNOWN Mass spectrometry 33796845   
PAPER GQSL*VLPC 163 UNKNOWN Mass spectrometry 33796845   
PAPER YFSN*VLPE 206 UNKNOWN Mass spectrometry 33796845   
PAPER AANL*SDTE 252 UNKNOWN Mass spectrometry 33796845   
PAPER SLEC*IAEG 292 UNKNOWN Mass spectrometry 33796845   
PAPER PIIY*WAKE 303 UNKNOWN Mass spectrometry 33796845   
PAPER VSEA*DSGN 333 UNKNOWN Mass spectrometry 33796845   
PAPER APYW*ITAP 363 UNKNOWN Mass spectrometry 33796845   
PAPER TAPQ*NLVL 368 UNKNOWN Mass spectrometry 33796845   
PAPER APQN*LVLS 369 UNKNOWN Mass spectrometry 33796845   
PAPER NLVL*SPGE 372 UNKNOWN Mass spectrometry 33796845   
PAPER LSPG*EDGT 375 UNKNOWN Mass spectrometry 33796845   
PAPER PGED*GTLI 377 UNKNOWN Mass spectrometry 33796845   
PAPER WLTN*GVPI 397 UNKNOWN Mass spectrometry 33796845   
PAPER LTNG*VPIE 398 UNKNOWN Mass spectrometry 33796845   
PAPER IAPD*DPSR 406 UNKNOWN Mass spectrometry 33796845   
PAPER APDD*PSRK 407 UNKNOWN Mass spectrometry 33796845   
PAPER RKID*GDTI 413 UNKNOWN Mass spectrometry 33796845   
PAPER KIDG*DTII 414 UNKNOWN Mass spectrometry 33796845   
ASCENT LLAN*AFVN 444 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER LHEN*GTLE 507 UNKNOWN Mass spectrometry 33796845   
PAPER HENG*TLEI 508 UNKNOWN Mass spectrometry 33796845   
PAPER VVQR*GSMV 559 UNKNOWN Mass spectrometry 33796845   
PAPER NPPF*DLEL 651 UNKNOWN Mass spectrometry 33796845   
PAPER PPFD*LELT 652 UNKNOWN Mass spectrometry 33796845   
PAPER QLDK*SVQL 661 UNKNOWN Mass spectrometry 33796845   
PAPER QLSW*TPGD 667 UNKNOWN Mass spectrometry 33796845   
PAPER WTPG*DDNN 670 UNKNOWN Mass spectrometry 33796845   
PAPER GDDN*NSPI 673 UNKNOWN Mass spectrometry 33796845   
PAPER LWHH*QTEV 696 UNKNOWN Mass spectrometry 33796845   
PAPER WHHQ*TEVS 697 UNKNOWN Mass spectrometry 33796845   
PAPER HHQT*EVSG 698 UNKNOWN Mass spectrometry 33796845   
PAPER EVSG*TQTT 702 UNKNOWN Mass spectrometry 33796845   
PAPER QLKL*SPYV 711 UNKNOWN Mass spectrometry 33796845   
PAPER YVNY*SFRV 717 UNKNOWN Mass spectrometry 33796845   
PAPER SIGK*SLPS 729 UNKNOWN Mass spectrometry 33796845   
PAPER IGKS*LPSE 730 UNKNOWN Mass spectrometry 33796845   
PAPER SLPS*EASE 733 UNKNOWN Mass spectrometry 33796845   
PAPER SEAS*EQYL 736 UNKNOWN Mass spectrometry 33796845   
PAPER EASE*QYLT 737 UNKNOWN Mass spectrometry 33796845   
PAPER ASEQ*YLTK 738 UNKNOWN Mass spectrometry 33796845   
PAPER KPLN*GFES 771 UNKNOWN Mass spectrometry 33796845   
PAPER PLNG*FESN 772 UNKNOWN Mass spectrometry 33796845   
PAPER LNGF*ESNG 773 UNKNOWN Mass spectrometry 33796845   
PAPER GFES*NGPG 775 UNKNOWN Mass spectrometry 33796845   
PAPER GTPT*FVPY 813 UNKNOWN Mass spectrometry 33796845   
PAPER FVPY*LIKV 817 UNKNOWN Mass spectrometry 33796845   
PAPER PEPA*VVMG 834 UNKNOWN Mass spectrometry 33796845   
ASCENT AVVM*GHSG 837 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER GHSG*EDLP 841 UNKNOWN Mass spectrometry 33796845   
PAPER HSGE*DLPM 842 UNKNOWN Mass spectrometry 33796845   
PAPER SPDR*VFNT 943 UNKNOWN Mass spectrometry 33796845   
PAPER DRVF*NTPE 945 UNKNOWN Mass spectrometry 33796845   
PAPER RVFN*TPEG 946 UNKNOWN Mass spectrometry 33796845   
PAPER TPEG*VPSA 950 UNKNOWN Mass spectrometry 33796845   
PAPER LEWD*PPSH 973 UNKNOWN Mass spectrometry 33796845   
PAPER SHPN*GILT 979 UNKNOWN Mass spectrometry 33796845   
PAPER HPNG*ILTE 980 UNKNOWN Mass spectrometry 33796845   
PAPER NSTH*ELGP 996 UNKNOWN Mass spectrometry 33796845   
PAPER AQTS*AGSG 1033 UNKNOWN Mass spectrometry 33796845   
PAPER QTSA*GSGS 1034 UNKNOWN Mass spectrometry 33796845   
PAPER TSAG*SGSQ 1035 UNKNOWN Mass spectrometry 33796845   
PAPER PAMA*SRQV 1158 UNKNOWN Mass spectrometry 33796845   
PAPER No_information metalloprotease 16357171   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Cerebrospinal fluid 17853512
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Cerebrospinal fluid 15582749
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 17081049
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(lung adenocarcinoma) 22896658
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(ovarian cancer) 22623176
HCSD non-small cell lung cancer 21262398
HCSD cancer(non small cell lung cancer) 19655816