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| UniProt ID |
Q92673 |
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| Entry Name |
SORL_HUMAN |
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| Protein Name |
Sortilin-related receptor |
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| Primary Gene Name |
SORL1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | Sortilin-related receptor (Sortilin,LR11) | |
| Cell Type | (CHO) Chinese hamster ovary cell | |
| Substrate Description | hormone signaling | |
| Substrate Function Category | central nervous system (neuron);disease | |
| Substrate Function Subtype | neuronal receptors | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cell receptor (VPS10 domain);cardiovascular disease | |
| Short Summary of Papers | shed versions of sorCS receptors may have wider functions as growth factor-binding proteins that with ligand binding capability; sLR11 levels were significantly associated with higher long-term adverse cardiac events in patients with cardiovascular disease | |
| Cleavage Information | NONE | |
| PMID | 16393139 |
| Substrate Name | LR11(SorLA,SORL1) | |
| Cell Type | ||
| Substrate Description | low density lipoprotein receptor, binds apolipoprotein E; implicated in the uptake of lipoproteins and of proteases. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | atherosclerosis; coronary stenosis; diabetic retinopathy | |
| Short Summary of Papers | the extracellular part of LR11 (soluble LR11) is released by proteolytic shedding; circulating soluble sLR11 is a biomarker for atherosclerosis, coronary stenosis and diabetic retinopathy | |
| Cleavage Information | NONE | |
| PMID | 24699135 25443876 20047743 22541650 |
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Start | End |
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2138 | 2158 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | M*ATRS | 1 | unknown peptidase | physiologically relevant | Mass spectroscopy | 17721511 | ||
| HPRD | KPLR*RKRS | 78 | Furin | 11294867 | ||||
| MEROPS | RRKR*SAAL | 81 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRKR*SAAL | 81 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRKR*SAAL | 81 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRKR*SAAL | 81 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRKR*SAAL | 81 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRKR*SAAL | 81 | furin | physiologically relevant | NONE | 11294867 | ||
| PAPER | RRKR*SAAL | 81 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | CSQD*PEFH | 1318 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | 24699135 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |