UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q924X1
Entry Name

EPGN_MOUSE
Protein Name

Epigen
Primary Gene Name

Epgn
Organism

Mus musculus (Mouse)
Molecular Function

Growth factor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name epigen
Cell Type mouse embryonic fibroblasts (MEF)
Substrate Description EGFR signaling, various signals in cell proliferation, survival and migration
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (EGFR)
Sheddase ADAM17
Shedding-related Disease growth factor (EGFR)
Short Summary of Papers soluble agonist of EGFR; activation of EGFR signaling
Cleavage Information ZNo-human; Q6UW88
PMID 18951988 17169360



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 109
Transmembrane
 		110 130



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 17169360   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA