UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q8WY21
Entry Name

SORC1_HUMAN
Protein Name

VPS10 domain-containing receptor SorCS1
Primary Gene Name

SORCS1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name SorCS1, VPS10 domain-containing receptor (SORCS1)
Cell Type (CHO) Chinese hamster ovary cell
Substrate Description hormone signaling
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; neuronal receptors
Sheddase ADAM17
Shedding-related Disease cell receptor (VPS10 domain)
Short Summary of Papers shed versions of sorCS receptors may have wider functions as growth factor-binding proteins that with ligand binding capability
Cleavage Information NONE
PMID 16393139



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		1100 1120



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 16393139   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Plasma/Serum 18795103