UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q8WXI7
Entry Name

MUC16_HUMAN
Protein Name

Mucin-16
Primary Gene Name

MUC16
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Mucin16 (MUC16,CA-125)
Cell Type
Substrate Description thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Substrate Function Category cell surface structure; disease
Substrate Function Subtype
Sheddase MT1-MMP
Shedding-related Disease mucous barriers (cell surface protein); cancer (ovarian cancer)
Short Summary of Papers shed MUC16/CA-125 is detectable in sera from ovarian cancer patients. active MT1-MMP expression in ovarian cancer cells induces MUC16/CA-125 ectodomain shedding, reducing adhesion to meso-mimetic cultures and to intact peritoneal explants.
Cleavage Information NONE
PMID 25205731



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		1 14451
Transmembrane
 		14452 14472



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information MT1-MMP 25205731   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Tear 16901338
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 16047309
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 16083276
Sys-BodyFluid Plasma/Serum 15822942
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(breast cancer) 24505115
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(ovarian cancer) 22623176
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
locate 17986452