UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q8VI56
Entry Name

LRP4_MOUSE
Protein Name

Low-density lipoprotein receptor-related protein 4
Primary Gene Name

Lrp4
Organism

Mus musculus (Mouse)
Molecular Function

Developmental protein
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name low-density lipoprotein receptor-related protein 4 (Lrp4)
Cell Type
Substrate Description formation and the maintenance of the neuromuscular junction (NMJ)
Substrate Function Category lipid (lipoprotein receptor famiy)
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell receptor
Short Summary of Papers ECDs of LRP4 may modulate cellular signaling by scavenging and neutralizing extracellular ligands, thereby preserving signaling thresholds that are critical for proper embryonic development
Cleavage Information ZNo-Human:
PMID 17227771



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 1725
Transmembrane
 		1726 1746



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloproteinase 17227771   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825