UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q8R5M8
Entry Name

CADM1_MOUSE
Protein Name

Cell adhesion molecule 1
Primary Gene Name

Cadm1
Organism

Mus musculus (Mouse)
Molecular Function

Developmental protein
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Tumor suppressor cell adhesion molecule 1 (CADM1)
Cell Type HEK293 (Human Embryonic Kidney 293 cells) , human osteosarcoma Saos-2
Substrate Description heterophilic cell-cell adhesion. Synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly . May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype cell adhesion molecule
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule
Short Summary of Papers shedding of CADM1 may result in protein downregulation, and module adhesion between cells
Cleavage Information NONE
PMID 22172944
Substrate Name Tumor suppressor cell adhesion molecule 1 (CADM1)
Cell Type lung alveolar epithelial cell, islet cells
Substrate Description
Substrate Function Category disease
Substrate Function Subtype Disease: idiopathic interstitial pneumonia (IIP); type 2 diabetic pancreata
Sheddase metalloproteinase (suggested from cross reference)
Shedding-related Disease idiopathic interstitial pneumonia (IIP), type 2 diabetic pancreata
Short Summary of Papers increased CADM1 α-shedding contributes to AEC (Lung alveolar epithelial cell) apoptosis in emphysematous lungs; increased CADM1 ectodomain shedding, promote apoptosis of beta cells
Cleavage Information NONE
PMID 26231557 24964098



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		48 388
Transmembrane
 		389 409



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM10 22172944   
PaperC No_information BACE2 Type I TMP proteomics 23430253   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER neuron 22728825
PAPER β-Cell 23430253
PAPER ovary 15815987