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|---|---|---|
| UniProt ID |
Q8R183 |
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| Entry Name |
TIMD2_MOUSE |
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| Protein Name |
T-cell immunoglobulin and mucin domain-containing protein 2 |
|
| Primary Gene Name |
Timd2 |
|
| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Receptor |
|
| Membrane Location |
Cell membrane |
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|---|
| Substrate Name | Tim-2 | |
| Cell Type | ||
| Substrate Description | regulation of T-cell function | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | TIM-2 plays a negative regulatory role in the immune system, shedding and loss of TIM-2 from the surface of immune cells might lead to exacerbated immune processes. | |
| Cleavage Information | ZNo-Human: | |
| PMID | 24164679 |
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|---|---|---|
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Start | End |
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22 | 231 |
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232 | 252 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | P---K (region) | 221* | ADAM10 | mutation | 24164679 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||