UniProt Summary
UniProt ID

Q8N441

Entry Name

FGRL1_HUMAN

Protein Name

Fibroblast growth factor receptor-like 1

Primary Gene Name

FGFRL1

Organism

Homo sapiens (Human)

Molecular Function

Receptor

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name Fibroblast growth factor receptor-like 1 (FGFRL1)
Cell Type
Substrate Description negative regulator of FGFR signaling, negative effect on cell proliferation
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase (unkown)
Shedding-related Disease growth factor receptor (FGFR)
Short Summary of Papers soluble FGFRL1 ectodomain is capable of binding to some FGF ligands
Cleavage Information NONE
PMID 19920134



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
25 378
Transmembrane
379 399



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PAAA*ARGP 24 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER VASS*SSAT 369 (unkown) 19920134   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 18795103
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(Liver metastasis in colorectal cancer) 23443137