UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q8IU80
Entry Name

TMPS6_HUMAN
Protein Name

Transmembrane protease serine 6
Primary Gene Name

TMPRSS6
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Serine protease
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Transmembrane protease serine 6 (Matriptase-2)
Cell Type HEK 293 cells (Human Embryonic Kidney 293 cells)
Substrate Description
Substrate Function Category disease
Substrate Function Subtype iron homeostasis,ron-refractory iron; Disease: deficiency anemia (IRIDA)
Sheddase Matriptase-2 (Transmembrane protease serine 6)
Shedding-related Disease deficiency anemia (IRIDA)
Short Summary of Papers Autoactivation, producing soluble fragments
Cleavage Information NONE
PMID 24867957



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		56 76
Extracellular
 		77 811



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER PSSR*IVGG 576 Transmembrane protease serine 6(Matriptase-2) mutation 24867957   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692