UniProt Summary
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Biological Literature Report of Shedding
Substrate Name Neuroligin-3
Cell Type neuron
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM10, MMP3, MMP9
Shedding-related Disease
Short Summary of Papers PKC-dependent signaling drives shedding of neuroligin-3, which reduces synapse strength.
Cleavage Information
PMID 30242227



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
35 686
Transmembrane
687 707



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
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