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| UniProt ID |
Q8BMF8 |
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| Entry Name |
GLDN_MOUSE |
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| Protein Name |
Gliomedin |
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| Primary Gene Name |
Gldn |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Secreted |
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| Substrate Name | gliomedin | |
| Cell Type | ||
| Substrate Description | ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | ligand | |
| Short Summary of Papers | secreted forms gliomedin generated by proteolytic cleavage binds to Schwann cells and is incorporated into the extracellular matrix (ECM) in a heparin-dependent manner, suggesting the involvement of heparan sulfate proteoglycans (HSPGs). the N-terminal region of gliomedin is required for its binding to neurofascin and NrCAM. | |
| Cleavage Information | NONE | |
| PMID | 17485493 |
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Start | End |
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18 | 38 |
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39 | 549 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RNKR*SHNG | 94 | furin | physiologically relevant | NONE | 17293346 | ||
| MEROPS | SMVP*IRVM | 121 | unknown peptidase | physiologically relevant | NONE | 17293346 | ||
| MEROPS | VPIR*VMID | 123 | unknown peptidase | physiologically relevant | NONE | 17293346 | ||
| MEROPS | VIPN*DDTL | 277 | procollagen C-peptidase | physiologically relevant | NONE | 17293346 | ||
| PAPER | VIPN*DDTL | 277 | (unknown) | 17485493 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||