UniProt Summary
UniProt ID

Q8BHK2

Entry Name

SCN3B_MOUSE

Protein Name

Sodium channel subunit beta-3

Primary Gene Name

Scn3b

Organism

Mus musculus (Mouse)

Molecular Function

Ion channel
Sodium channel
Voltage-gated channel

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name Sodium channel subunit beta 3 (Scn3b)
Cell Type
Substrate Description assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel;required to reconstitute full properties of the native sodium channel
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase BACE1 (memapsin-2)
Shedding-related Disease ion channel
Short Summary of Papers β subunits of voltage-gated sodium channels are processed by BACE1 and γ-secretase (regulated intramembrane proteolysis) sequentially; shed ectodomain may be required for β subunit-mediated neurite outgrowth
Cleavage Information ZNo-Human:
PMID 15824102 18694383



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
25 159
Transmembrane
160 180



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS EFEF*EAHR 128 memapsin-2 physiologically relevant NONE 15824102   
MEROPS GEDF*TSVV 153 memapsin-2 physiologically relevant NONE 15824102   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA