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|---|---|---|
| UniProt ID |
Q8BHK2 |
|
| Entry Name |
SCN3B_MOUSE |
|
| Protein Name |
Sodium channel subunit beta-3 |
|
| Primary Gene Name |
Scn3b |
|
| Organism |
Mus musculus (Mouse) |
|
| Molecular Function |
Ion channel |
|
| Membrane Location |
Membrane |
|
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|---|
| Substrate Name | Sodium channel subunit beta 3 (Scn3b) | |
| Cell Type | ||
| Substrate Description | assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel;required to reconstitute full properties of the native sodium channel | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | BACE1 (memapsin-2) | |
| Shedding-related Disease | ion channel | |
| Short Summary of Papers | β subunits of voltage-gated sodium channels are processed by BACE1 and γ-secretase (regulated intramembrane proteolysis) sequentially; shed ectodomain may be required for β subunit-mediated neurite outgrowth | |
| Cleavage Information | ZNo-Human: | |
| PMID | 15824102 18694383 |
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|---|---|---|
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Start | End |
|
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25 | 159 |
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160 | 180 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | EFEF*EAHR | 128 | memapsin-2 | physiologically relevant | NONE | 15824102 | ||
| MEROPS | GEDF*TSVV | 153 | memapsin-2 | physiologically relevant | NONE | 15824102 | ||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |