UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q8BGV3
Entry Name

TACD2_MOUSE
Protein Name

Tumor-associated calcium signal transducer 2
Primary Gene Name

Tacstd2
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Trop2
Cell Type
Substrate Description may function as a growth factor receptor.
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease growth factor receptor
Short Summary of Papers Trop2 undergo ecotodomain shedding and RIP (regulated intramembrane proteolysis), the proteolysis process of Trop2 drives self-renewal signaling via β-catenin
Cleavage Information ZNo-Human:
PMID 20551327



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 270
Transmembrane
 		271 291



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER FLSA*VHYE 187 ADAM17 20551327   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA