UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q86YW5
Entry Name

TRML1_HUMAN
Protein Name

Trem-like transcript 1 protein
Primary Gene Name

TREML1
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name triggering receptor expressed on myeloid cells like transcript-1 (TLT-1)
Cell Type
Substrate Description cell surface receptor that may play a role in the innate and adaptive immune response
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor
Short Summary of Papers soluble TLT-1 is released from platelets and detected in serum, and the fragment formed from TLT-1 residues is hypothesized to functions analogously to block TLT-1 binding to its natural partner, thereby inhibiting TLT-1 signaling
Cleavage Information ZNo-Human:
PMID 16505478



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		16 162
Transmembrane
 		163 183



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 16505478   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER platelet 20962327