UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q86VB7
Entry Name

C163A_HUMAN
Protein Name

Scavenger receptor cysteine-rich type 1 protein M130
Primary Gene Name

CD163
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Scavenger receptor cysteine-rich type 1 protein M130(CD163)
Cell Type
Substrate Description endocytosis of hemoglobin/haptoglobin complexes by macrophages
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease cell receptor
Short Summary of Papers the shed sCD163 may be regarded as a surrogate marker of the rapidly cleared TNF-α released from macrophages in inflammation
Cleavage Information NONE
PMID 20807704



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		42 1050
Transmembrane
 		1051 1071



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD RLVD*GVTE 270 15448162   
HPRD RLVD*GVTE 270 15448162   
HPRD LEVR*FQGE 282 15448162   
HPRD LEVR*FQGE 282 15448162   
HPRD DSVS*CQGH 334 15448162   
HPRD DSVS*CQGH 334 15448162   
HPRD NEDA*GVTC 361 15448162   
HPRD NEDA*GVTC 361 15448162   
PAPER No_information ADAM17 20807704   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 16739989
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Cerebrospinal fluid 15582749
Sys-BodyFluid Cerebrospinal fluid 17022648
HCSD cancer(ovarian cancer) 22623176
locate 17986452