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| UniProt ID |
Q86T13 |
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| Entry Name |
CLC14_HUMAN |
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| Protein Name |
C-type lectin domain family 14 member A |
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| Primary Gene Name |
CLEC14A |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Membrane |
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| Substrate Name | CLEC14A (EGFR5,C14orf27) | |
| Cell Type | ||
| Substrate Description | C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily protein, regulates endothelial cell function, involved in cell adhesion and angiogenesis. | |
| Substrate Function Category | angiogenesis | |
| Substrate Function Subtype | ||
| Sheddase | RHBDL2 | |
| Shedding-related Disease | growth factor receptor (EGFR) | |
| Short Summary of Papers | the ectodomain of CLEC14A, catalyzed by rhomboidlike 2 protein (RHBDL2), regulates sprouting angiogenesis | |
| Cleavage Information | NONE | |
| PMID | 26939791 |
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Start | End |
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22 | 397 |
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398 | 418 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PGGG*EHPT | 21 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| PAPER | AFDS*SSAV | 394 | RHBDL2 | 26939791 | ||||