UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q86SQ4
Entry Name

AGRG6_HUMAN
Protein Name

Adhesion G-protein coupled receptor G6
Primary Gene Name

ADGRG6
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Adhesion G Protein-Coupled Receptor G6(GPR126,DREG)
Cell Type
Substrate Description adhesion-class G protein-coupled receptor, normal differentiation of promyelinating Schwann cells, normal myelination of axons
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase proprotein convertase
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers the shedding of DREG may implied that DREG may function both as a receptor and a ligand
Cleavage Information NONE
PMID 15189448



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		38 862
Transmembrane
 		863 883
Transmembrane
 		904 924
Extracellular
 		925 929
Transmembrane
 		930 950
Transmembrane
 		971 991
Extracellular
 		992 1024
Transmembrane
 		1025 1045
Transmembrane
 		1070 1090
Extracellular
 		1091 1092
Transmembrane
 		1093 1113



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD KVKR*SLED 468 15189448   
HPRD KVKR*SLED 468 15189448   
HPRD CNHF*THFG 840 15189448   
HPRD CNHF*THFG 840 15189448   
HPRD CNHF*THFG 840 15189448   
HPRD CNHF*THFG 840 15189448   
PAPER CNHF*THFG 840 UNKNOWN Mass spectrometry 33796845   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 24418523
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(oral cancer ) 21714544
HCSD cancer(metastatic non-small-cell lung cancer) 24667143
HCSD cancer(Liver metastasis in colorectal cancer) 23443137