UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q7Z7D3
Entry Name

VTCN1_HUMAN
Protein Name

V-set domain-containing T-cell activation inhibitor 1
Primary Gene Name

VTCN1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name T-cell activation inhibitor-1 (VTCN1,B7-H4)
Cell Type
Substrate Description negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase metalloproteinase nardilysin
Shedding-related Disease ligand
Short Summary of Papers membrane-tethered VTCN1 undergoes proteolytic cleavage mediated by the metalloproteinase nardilysin, the blood sVTCN1 levels may be of potential use as type 1 diabetes biomarker.
Cleavage Information NONE
PMID 24848066



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 259
Transmembrane
 		260 280



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloproteinase nardilysin 24848066   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836