UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q7TSU7
Entry Name

KIRR2_MOUSE
Protein Name

Kin of IRRE-like protein 2
Primary Gene Name

Kirrel2
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Kin of IRRE-like protein 2(Kirrel2)
Cell Type
Substrate Description homotypic interactions,expressed in pancreatic β-cells, regulates basal insulin secretion
Substrate Function Category insulin
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell surface protein
Short Summary of Papers the extracellular domain of Kirrel2 is shed, followed by regulated intramembrane proteolysis by γ-secretase
Cleavage Information ZNo-Human:
PMID 26324709



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 507
Transmembrane
 		508 528



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER SVLH*ISGT 467 (unknown) 26324709   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825