UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q78IQ7
Entry Name

S39A4_MOUSE
Protein Name

Zinc transporter ZIP4
Primary Gene Name

Slc39a4
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Zinc Transporter ZIP4 (SLC39A4)
Cell Type
Substrate Description cellular zinc homeostasis as a zinc transporter. regulated in response to zinc availability.
Substrate Function Category transporter
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease ion
Short Summary of Papers proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency. the processing of ZIP4 may represent a significant regulatory mechanism controlling its function.
Cleavage Information ZNo-Human:
PMID 18936158



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		23 337
Transmembrane
 		338 358
Transmembrane
 		377 397
Extracellular
 		398 420
Transmembrane
 		421 441
Transmembrane
 		572 592
Extracellular
 		593 599
Transmembrane
 		600 620
Transmembrane
 		631 651
Extracellular
 		652 660



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER LVQQ*QLSG 313 metalloproteinase mutation 18936158   
PAPER SGAC*SPYP 319 metalloproteinase mutation 18936158   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA