UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6ZVN8
Entry Name

RGMC_HUMAN
Protein Name

Hemojuvelin
Primary Gene Name

HJV
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Hemojuvelin
Cell Type HepG2 (liver hepatocellular cells), HEK293 (human embryonic kidney)
Substrate Description regulation of hepcidin expression.
Substrate Function Category blood and homoeostasis
Substrate Function Subtype iron homeostasis
Sheddase Matriptase-2 (Transmembrane protease serine 6)
Shedding-related Disease iron homeostasis
Short Summary of Papers cleavage of hemojuvelin releases HJV, negatively regulating BMP signaling
Cleavage Information GPI-anchor
PMID 20937842



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER IIIR*QTAG 288 Transmembrane protease serine 6(Matriptase-2) 20937842   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692