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| UniProt ID |
Q6YHK3 |
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| Entry Name |
CD109_HUMAN |
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| Protein Name |
CD109 antigen |
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| Primary Gene Name |
CD109 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Serine protease inhibitor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | CD109 | |
| Cell Type | ||
| Substrate Description | modulates negatively TGFB1 signaling in keratinocytes | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | mesotrypsin | |
| Shedding-related Disease | growth factor receptor regulator; cell surface protein | |
| Short Summary of Papers | mesotrypsin cleavage releases CD109 from the cell surface. CD109 shed from the cell surface by mesotrypsin participates in a pro-growth signaling function. | |
| Cleavage Information | GPI-anchor | |
| PMID | 20035377 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | AALA*VAPG | 21 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 14980714 | ||
| PAPER | VYDN*AEYA | 657 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DNAE*YAER | 659 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | EYAE*RFME | 662 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | MEEN*EGHI | 668 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | AFDL*DVAV | 1283 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | PSEA*ISLS | 1330 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | mesotrypsin | 20035377 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(metastatic non-small-cell lung cancer) | 24667143 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |