UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6VNS1
Entry Name

NTRK3_MOUSE
Protein Name

NT-3 growth factor receptor
Primary Gene Name

Ntrk3
Organism

Mus musculus (Mouse)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name TrkC receptor (TrkCNC2)
Cell Type
Substrate Description receptor tyrosine kinase involved in nervous system and probably heart development.
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease cell receptor
Short Summary of Papers the noncatalytic TrkCNC2 receptor is cleaved by metalloproteases upon neurotrophin-3 stimulation, soluble ectodomain is generated in the cell culture medium. ectodomain shedding represents a novel means of regulating TrkC receptor signaling.
Cleavage Information ZNo-Human:
PMID 12569366



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 429
Transmembrane
 		430 453



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloprotease 12569366   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA