UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6UVK1
Entry Name

CSPG4_HUMAN
Protein Name

Chondroitin sulfate proteoglycan 4
Primary Gene Name

CSPG4
Organism

Homo sapiens (Human)
Molecular Function

Developmental protein
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Chondroitin sulfate proteoglycan 4 (NG2)
Cell Type
Substrate Description proteoglycan invovled in cell proliferation and migration, neurite outgrowth inhibition
Substrate Function Category cell surface structure
Substrate Function Subtype cell adhesion molecule
Sheddase metalloproteinase
Shedding-related Disease proteoglycan
Short Summary of Papers shedding of NG2 represents a mechanism for decreasing responsiveness to PDGF, involved in the control of cell proliferation
Cleavage Information NONE
PMID 15866049



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		30 2224
Transmembrane
 		2225 2245



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS SLSQ*QQLR 1963 matrix metallopeptidase-2 not physiologically relevant Mass spectroscopy 18500335   
MEROPS SDRE*EPEA 1973 glutamyl peptidase I not physiologically relevant Mass spectroscopy 18500335   
PAPER PRAR*TEPG 2101 UNKNOWN Mass spectrometry 33796845   
ASCENT ARPY*SVAL 2171 UNKNOWN subtiligase-based N-terminal sequencing 33536314   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16948836
HCSD cancer (gastric cancer) 23161554
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 22623176
HCSD cancer(oral cancer ) 21714544
HCSD cancer(Glioblastoma) 23483059