UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6Q473
Entry Name

CLA4A_MOUSE
Protein Name

Calcium-activated chloride channel regulator 4A
Primary Gene Name

Clca4a
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Protease
Metalloprotease
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name calcium-activated chloride channel regulators (CLCA6)
Cell Type
Substrate Description involved in mediating calcium-activated chloride conductance.
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase CLCA6, metalloprotease
Shedding-related Disease ion channel
Short Summary of Papers impaired autoproteolytic cleavage of mCLCA6 leads to cleavage at the plasma membrane by a metalloprotease.
Cleavage Information ZNo-Human:
PMID 22350745



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		884 904



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information CLCA6,metalloprotease 22350745   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825