UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6P5F6
Entry Name

S39AA_MOUSE
Protein Name

Zinc transporter ZIP10
Primary Gene Name

Slc39a10
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Zinc transporter ZIP10
Cell Type
Substrate Description may act as a zinc-influx transporter
Substrate Function Category transporter
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease ion
Short Summary of Papers starving cells of manganese or zinc causes ectodomain shedding of the ZIP10 and shedding of the N1 fragment of PrP(C). the results in the study suggests that manganese or zinc starvation may contribute to the etiology of prion disease in mice.
Cleavage Information ZNo-Human:
PMID 22687393



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		413 433
Transmembrane
 		440 460
Transmembrane
 		497 517
Transmembrane
 		689 709
Transmembrane
 		734 754
Transmembrane
 		761 781
Transmembrane
 		803 823



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 22687393   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER macrophage 24396086