UniProt Summary
UniProt ID

Q6P1D5

Entry Name

SE6L1_MOUSE

Protein Name

Seizure 6-like protein

Primary Gene Name

Sez6l

Organism

Mus musculus (Mouse)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name Seizure 6-like protein (SEZ6L)
Cell Type pancreatic β-cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase BACE1, BACE2
Shedding-related Disease
Short Summary of Papers SEZ6L is one of the substrates of BACE1 and BACE2.
Cleavage Information
PMID 23430253



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
32 897
Transmembrane
898 918



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PaperC EHAL*EAEA 881 BACE2 Type I TMP proteomics, Western blot 23430253   
PaperC No_information BACE1 Type I proteomics 22728825   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER neuron 22728825
PAPER β-Cell 23430253