UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6P1B3
Entry Name

PIANP_MOUSE
Protein Name

PILR alpha-associated neural protein
Primary Gene Name

Pianp
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Leda-1/Pianp
Cell Type CHO, HEK 293 T and B16F10 cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM10, ADAM17, MMPs
Shedding-related Disease
Short Summary of Papers Leda-1/Pianp is shed and cleaved by MMPs, ADAM10/17.
Cleavage Information
PMID 27349870



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		28 174
Transmembrane
 		175 195



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PAQG*SSHR 27 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825