UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q6DR99
Entry Name

Q6DR99_MOUSE
Protein Name

Neuregulin 1
Primary Gene Name

Nrg1
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name neuregulins (NRG)
Cell Type vascular endothelial cells (ECs)
Substrate Description ERBB receptors signaling
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (ERBBs)
Sheddase ADAM17
Shedding-related Disease growth factor (ERBBs)
Short Summary of Papers release of extracellular epidermal growth factor-like-containing domain as soluble agonist of ErbB3 and ErbB4
Cleavage Information NONE
PMID 18951988 20215529



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		76 99
Transmembrane
 		303 325



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 15936750   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA