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| UniProt ID |
Q68D85 |
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| Entry Name |
NR3L1_HUMAN |
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| Protein Name |
Natural cytotoxicity triggering receptor 3 ligand 1 |
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| Primary Gene Name |
NCR3LG1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | B7-H6 | |
| Cell Type | tumor cells | |
| Substrate Description | tumor escape mechanisms | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (cancer escape targeting by NK), immuno therapy | |
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cancer (tumor escape targeting by NK and immuno therapy) | |
| Short Summary of Papers | shedding of B7-H6 may be involved in immune escape of tumor cells | |
| Cleavage Information | NONE | |
| PMID | 24780758 |
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Start | End |
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25 | 262 |
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263 | 283 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PASR*LLLD | 146 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | VGMK*ENED | 155 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| ASCENT | VRHA*SLHT | 233 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | metalloprotease | 24780758 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |