UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q64605
Entry Name

PTPRS_RAT
Protein Name

Receptor-type tyrosine-protein phosphatase S
Primary Gene Name

Ptprs
Organism

Rattus norvegicus (Rat)
Molecular Function

Hydrolase
Protein phosphatase
Receptor
Heparin-binding
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Receptor-type tyrosine-protein phosphatase sigma (RPTPĪƒ)
Cell Type
Substrate Description protein tyrosine phosphatase (PTP) family. regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. interacts with LAR-interacting protein LIP
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease receptor-type PTPases
Short Summary of Papers shedding of the extracellular domain results in the internalization and redistribution of catalytically active intracellular portions of PTPasesand and may regulate the activity and target specificity PTPases.
Cleavage Information ZNo-Human:
PMID 9245795



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		30 1257
Transmembrane
 		1258 1278



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER DPQP*IVDG 1250 (unknown) 9245795   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825