UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q63155
Entry Name

DCC_RAT
Protein Name

Netrin receptor DCC
Primary Gene Name

Dcc
Organism

Rattus norvegicus (Rat)
Molecular Function

Developmental protein
Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Netrin receptor DCC
Cell Type
Substrate Description receptor for netrin required for axon guidance. axon attraction of neuronal growth cones in the developing nervous system.
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease cell receptor
Short Summary of Papers DCC is subject to ectodomain shedding by metalloprotease and the proteolytic cleavage by metalloprotease may regulate axon migration by controlling the number of functional extracellular axon guidance receptors
Cleavage Information ZNo-Human:
PMID 10958786



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		1100 1120



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloprotease 10958786   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA