UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q62170
Entry Name

SELPL_MOUSE
Protein Name

P-selectin glycoprotein ligand 1
Primary Gene Name

Selplg
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name P-selectin glycoprotein ligand 1 (PSGL-1, CD162)
Cell Type
Substrate Description leukocyte adhesion in inflammatory reactions
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase BACE1, ADAM8
Shedding-related Disease ligand
Short Summary of Papers the shedding of PSGL-1 mediated by ADAM8 enhanced invasiveness of neutrophils into injured muscle fibers by the removal of their adhesiveness to blood vessels; PSGL-1 is also cleavaged by BACE1.
Cleavage Information NONE
PMID 14507929 25511460



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		18 307
Transmembrane
 		308 328



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER SGLK*KGLI 280 metalloprotease NONE 16542157   
PAPER GLKK*GLIV 281 metalloprotease NONE 16542157   
PAPER No_information ADAM8 25511460   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825