UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q61851
Entry Name

FGFR3_MOUSE
Protein Name

Fibroblast growth factor receptor 3
Primary Gene Name

Fgfr3
Organism

Mus musculus (Mouse)
Molecular Function

Kinase
Tyrosine-protein kinase
Transferase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name FGFR3
Cell Type
Substrate Description cell-surface receptor for fibroblast growth factor,regulation of cell proliferation, differentiation and apoptosis, negative regulator of linear bone growth
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase ADAM10, ADAM17
Shedding-related Disease growth factor receptor (FGFR)
Short Summary of Papers FGF1 induces ectodomain cleavage and intramembrane cleavage (regulated intramembrane proteolysis and nuclear localization) of FGFR3.
Cleavage Information ZNo-Human:
PMID 21865593



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 369
Transmembrane
 		370 390



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER EELM*ETDE 358 ADAM10,ADAM17 21865593   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825