UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q61790
Entry Name

LAG3_MOUSE
Protein Name

Lymphocyte activation gene 3 protein
Primary Gene Name

Lag3
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD223 (LAG-3)
Cell Type lymphocytes
Substrate Description Leukocyte Recruitment, Leukocyte and endothelial cell activation and immune modulation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; receptor (lymphocyte activation)
Sheddase MMP/ADAM
Shedding-related Disease cell receptor
Short Summary of Papers LAG-3 cleavage allow efficient T-cell proliferation and cytokine production
Cleavage Information ZNo-human; P18627
PMID 16565325 17245433
Substrate Name Lymphocyte activation gene 3 protein(LAG-3,CD223)
Cell Type
Substrate Description lymphocyte activation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM10, ADAM17
Shedding-related Disease cell receptor
Short Summary of Papers shedding of LAG-3 by metalloproteinases regulates T-cell proliferation and effector function
Cleavage Information ZNo-Human:
PMID 17245433



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		24 442
Transmembrane
 		443 463



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PMAP No_information ADAM17 peptidase This_entry_is_based_on_an_experiment. Gel electrophoresis 17245433   
PMAP No_information ADAM10 peptidase This_entry_is_based_on_an_experiment. Gel electrophoresis 17245433   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA