UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q61521
Entry Name

EREG_MOUSE
Protein Name

Proepiregulin [Cleaved into: Epiregulin
Primary Gene Name

Ereg
Organism

Mus musculus (Mouse)
Molecular Function

Mitogen
Developmental protein
Growth factor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name epiregulin (EREG)
Cell Type
Substrate Description EGFR signaling, various signals in cell proliferation, survival and migration
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (EGFR)
Sheddase ADAM17
Shedding-related Disease growth factor (EGFR)
Short Summary of Papers release ectodomain (soluble EGFR-ligands) to activate EGFR signaling
Cleavage Information NONE
PMID 19049889 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		53 112
Transmembrane
 		113 133



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PMAP No_information ADAM17 peptidase This_entry_is_based_on_an_experiment. 14993236   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA