UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q61483
Entry Name

DLL1_MOUSE
Protein Name

Delta-like protein 1
Primary Gene Name

Dll1
Organism

Mus musculus (Mouse)
Molecular Function

Developmental protein
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Delta-like protein 1 (Dll-1)
Cell Type
Substrate Description cell fate determination and development; neuronal differentiation
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; ligand
Sheddase ADAM12, ADAM10, ADAM17
Shedding-related Disease ligand
Short Summary of Papers shedding of Dll-1 ectodomain, followed by RIP (regulated intramembrane proteolysis)
Cleavage Information ZNo-human;O00548
PMID 18342566 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		18 545
Transmembrane
 		546 568



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS SERH*MESQ 535 ADAM10 peptidase physiologically relevant NONE 12794186   
PAPER No_information ADAM12 physiologically relevant Gel Electrophoresis 17107962   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825