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| UniProt ID |
Q61180 |
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| Entry Name |
SCNNA_MOUSE |
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| Protein Name |
Amiloride-sensitive sodium channel subunit alpha |
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| Primary Gene Name |
Scnn1a |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Ion channel |
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| Membrane Location |
Cell membrane |
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| Substrate Name | epithelial sodium channel (ENaC) alpha subunit | |
| Cell Type | ||
| Substrate Description | electrodiffusion of the luminal sodium and water, electrolyte and blood pressure homeostasis | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | furin | |
| Shedding-related Disease | ion channel | |
| Short Summary of Papers | furin-mediated proteolysis on the extracellular domain of ENaC α subunit module sodium channel activation | |
| Cleavage Information | ZNo-Human: | |
| PMID | 15007080 |
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Start | End |
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111 | 131 |
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132 | 589 |
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590 | 610 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RSTR*DLRG | 205 | furin | physiologically relevant | mutation | 15466477 | ||
| PMAP | RSTR*DLRG | 205 | furin | This_entry_is_based_on_an_experiment. | Mutagenesis | 15466477 | ||
| MEROPS | RSAR*SASS | 231 | furin | physiologically relevant | mutation | 15466477 | ||
| PMAP | RSAR*SASS | 231 | furin | This_entry_is_based_on_an_experiment. | Mutagenesis | 15466477 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |