UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q60819
Entry Name

I15RA_MOUSE
Protein Name

Interleukin-15 receptor subunit alpha
Primary Gene Name

Il15ra
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Secreted
Membrane



Biological Literature Report of Shedding
Substrate Name IL-15R
Cell Type lymphocytes
Substrate Description Leukocyte Recruitment - Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor
Sheddase ADAM17
Shedding-related Disease cytokine receptor
Short Summary of Papers soluble IL-15 antagonist, enhanced proinflammatory cytokines
Cleavage Information NONE
PMID 16565325 15265897



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		33 205
Transmembrane
 		206 226



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PMAP No_information ADAM17 peptidase This_entry_is_based_on_an_experiment. Gel electrophoresis 15215246    17327231   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825