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|---|---|---|
| UniProt ID |
Q5ZPR3 |
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| Entry Name |
CD276_HUMAN |
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| Protein Name |
CD276 antigen |
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| Primary Gene Name |
CD276 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Membrane |
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| Substrate Name | B7-H3(CD276) | |
| Cell Type | ||
| Substrate Description | may participate in the regulation of T-cell-mediated immune response | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | ligand | |
| Short Summary of Papers | cleavage of sB7-H3 to an active soluble form by metalloproteinase would alter both proximal and distal cellular responses. | |
| Cleavage Information | NONE | |
| PMID | 18194267 |
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Start | End |
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29 | 466 |
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467 | 487 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LTGA*LEVQ | 28 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| PAPER | VSLQ*VAAP | 137 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | metalloproteinase | 18194267 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |