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| UniProt ID |
Q5VWK5 |
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| Entry Name |
IL23R_HUMAN |
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| Protein Name |
Interleukin-23 receptor |
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| Primary Gene Name |
IL23R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | IL-23R | |
| Cell Type | ||
| Substrate Description | associates with IL12RB1 to form the interleukin-23 receptor. binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | IL-23R undergoes ectodomain shedding by ADAM10 and ADAM17, and shedding of IL-23R might contribute to negative regulation of IL-23-signaling. | |
| Cleavage Information | NONE | |
| PMID | 26961870 |
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Start | End |
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24 | 355 |
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356 | 376 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | V | 319 | ADAM10,ADAM17 | mutation | 26961870 | |||
| PAPER | V | 322 | ADAM10,ADAM17 | mutation | 26961870 | |||
| MEROPS | WCHG*GITN | unknown peptidase | physiologically relevant | Mass spectroscopy | 26796116 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |