UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q56A07
Entry Name

SCN2B_MOUSE
Protein Name

Sodium channel subunit beta-2
Primary Gene Name

Scn2b
Organism

Mus musculus (Mouse)
Molecular Function

Ion channel
Sodium channel
Voltage-gated channel
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Sodium channel subunit beta 2 (Scn2b)
Cell Type
Substrate Description assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel;required to reconstitute full properties of the native sodium channel
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase BACE1 (memapsin-2)
Shedding-related Disease ion channel
Short Summary of Papers β subunits of voltage-gated sodium channels are processed by BACE1 and γ-secretase (regulated intramembrane proteolysis) sequentially; shed ectodomain may be required for β subunit-mediated neurite outgrowth
Cleavage Information ZNo-Human:
PMID 15824102 18694383



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		30 159
Transmembrane
 		160 180



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS KIYL*QVLL 144 memapsin-2 physiologically relevant NONE 15824102   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA