UniProt Summary
UniProt ID

Q4V9Z5

Entry Name

SE6L2_MOUSE

Protein Name

Seizure 6-like protein 2

Primary Gene Name

Sez6l2

Organism

Mus musculus (Mouse)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name SEZ6L2
Cell Type pancreatic β-cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase BACE1, BACE2
Shedding-related Disease
Short Summary of Papers SEZ6L2 is one of the substrates of BACE1 and BACE2 in pancreatic beta-cells.
Cleavage Information
PMID 23430253



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
28 844
Transmembrane
845 865



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PaperC No_information BACE1 Type I proteomics 22728825   
PaperC No_information BACE1/2 Type I TMP proteomics, Western blot 23430253   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
PAPER β-Cell 23430253
PAPER ovary 15815987