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| UniProt ID |
Q29983 |
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| Entry Name |
MICA_HUMAN |
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| Protein Name |
MHC class I polypeptide-related sequence A |
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| Primary Gene Name |
MICA |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | NKG2D ligand (MICA) | |
| Cell Type | tumor cells | |
| Substrate Description | invovled in tumor escape mechanisms | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (cancer escape targeting by NK), immuno therapy | |
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cancer (tumor escape targeting by NK and immuno therapy) | |
| Short Summary of Papers | NKG2D ligands shedding regulate the escape of malignant cells from stress-elicited immune responses | |
| Cleavage Information | NONE | |
| PMID | 21389869 26161387 18676862 |
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Start | End |
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24 | 307 |
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308 | 328 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | HPVP*SGKV | 296 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PAPER | PVPS*GKVL | 297 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PAPER | VPSG*KVLV | 298 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PAPER | PSGK*VLVL | 299 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PAPER | GKVL*VLQS | 301 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PAPER | KVLV*LQSH | 302 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PAPER | LVLQ*SHWQ | 304 | ADAM17 | Mass spectroscopy | 18676862 | |||
| PMAP | No_information | matrix metallopeptidase | This entry is a predicted | 12370336 | ||||