|
|
||
|---|---|---|
| UniProt ID |
Q29980 |
|
| Entry Name |
MICB_HUMAN |
|
| Protein Name |
MHC class I polypeptide-related sequence B |
|
| Primary Gene Name |
MICB |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function | ||
| Membrane Location |
Cell membrane |
|
|
|
|---|
| Substrate Name | MICB | |
| Cell Type | tumor cells, sera of cancer patients. | |
| Substrate Description | tumor escape mechanisms | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (cancer targeting by NK), immuno therapy | |
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cancer (tumor escape targeting by NK and immuno therapy) | |
| Short Summary of Papers | proteolytic shedding of MICB by tumor cells may impair immunogenicity of tumors | |
| Cleavage Information | NONE | |
| PMID | 16698441 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
23 | 309 |
|
|
310 | 330 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | metallopeptidase | 21389869 | |||||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |